Which medication class is often used to manage mild to moderate pain in musculoskeletal conditions?

Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently utilized in managing mild to moderate pain associated with musculoskeletal conditions. This is due to their effectiveness in reducing pain and inflammation, which are common symptoms in various musculoskeletal disorders. NSAIDs work by inhibiting specific enzymes (COX-1 and COX-2) involved in the production of prostaglandins, the chemicals responsible for pain and inflammation in the body.

Their ability to provide symptomatic relief makes them a first-line treatment option for conditions such as arthritis, muscle strains, and other inflammatory disorders, addressing both the pain and the underlying inflammation. Additionally, NSAIDs have a relatively favorable safety profile when used as directed, making them suitable for a wide range of patients compared to other classes of medications.

While opioids can be effective for more severe pain, they carry a higher risk of dependency and are not typically recommended for mild to moderate pain management. Antibiotics target infections, and antidepressants, although sometimes used for chronic pain management, are not primarily indicated for acute musculoskeletal pain. Thus, NSAIDs are the most appropriate and frequently used class for managing mild to moderate musculoskeletal pain.